Engineered bacteria to report gut function: technologies and implementation

Advances in synthetic biology and microbiology have enabled the creation of engineered bacteria which can sense report on intracellular extracellular signals. When deployed vivo these whole-cell bacterial biosensors act as sentinels to monitor biomolecules interest human health disease settings. This is particularly interesting context gut microbiota, interacts extensively with host throughout time transit be accessed from feces without requiring invasive collection. Leveraging rational engineering approaches for genetic circuits well an expanding catalog disease-associated biomarkers, non-invasive easy-to-monitor reporters gut. Here, we summarize recent applied animal models then highlight promising technologies designing next generation biosensors.